Louisville dominated Villanova 59-13 in a lopsided Week 2 matchup, with the Cardinals' offense putting on a showcase performance behind quarterback Lincoln Kienholz's 332 passing yards.

The Cardinals jumped out to an early lead, with Kienholz connecting with J. Skinner on a 69-yard touchdown pass in the first quarter. Louisville's offensive firepower continued throughout the second quarter, scoring three touchdowns in the period alone—including a 61-yard scoring pass to L. McCoy and a rushing touchdown from Kienholz—to effectively put the game out of reach.

Villanova managed a touchdown response when P. McQuaide found J. Mace for a 65-yard scoring strike in the second quarter, but the Wildcats couldn't generate sustained momentum against Louisville's defense.

Louisville's balanced attack was evident in the statistical leaders: Kienholz led the passing game, Tre Richardson paced receivers with 98 yards, and Marquise Davis led rushers with 86 yards. The Cardinals' defense limited Villanova to just 13 points while scoring consistently throughout all four quarters.