Michigan State overwhelmed Western Michigan 23-6 in Week 1 of the 2025 season, with the Spartans controlling most of the game before a quiet fourth quarter. Michigan State jumped out to an early lead, scoring 7 points in the first quarter and extending that to 14 by halftime. The defense added a safety in the third quarter to push the lead to 23-0.

Western Michigan's offense struggled for most of the contest, with Brady Jones completing 97 passing yards and Baylin Brooks leading receivers with 85 yards. The Broncos managed only 6 points, scoring their lone touchdown in the fourth quarter. A critical fourth-quarter play saw Michigan State's Tate Hallock return an interception 32 yards, though the subsequent two-point conversion attempt failed.

Despite the dominant scoreline, the game came in well under the 50-point over-under line. Western Michigan's defense generated some resistance in the third quarter, forcing Michigan State into difficult situations, but the Spartans' early offensive success proved decisive in securing the convincing home victory.