Oregon overwhelmed Washington 49-21 in Week 14, with the Ducks' defense suffocating the Huskies throughout the contest. Oregon's dominant second quarter, which produced 21 points, proved decisive in establishing control early. The home team maintained momentum with 14 fourth-quarter points to put the game out of reach.

Dante Moore led Oregon's passing attack with 27 completions, while running back Jordan James rushed for 99 yards. Washington's receiving corps was led by Adam Mohammed with 8 catches, but the Huskies managed only 3 points in the first quarter and were shut out entirely in the third.

Oregon's defense generated the game's most impactful plays, with a crucial defensive stop in the fourth quarter providing the largest EPA swing (3.28). Despite Washington's late offensive efforts, including a touchdown pass from Demond Williams Jr. to Giles Jackson, the Ducks' defense consistently stifled Washington's drives. The game exceeded the over-under of 51 points, and Oregon easily covered the 17.5-point spread, dominating a conference matchup in which lead changes were minimal.